ALEXIS Biochemicals: Z-VAD(OMe)-FMK

ALX-260-039

Revised 05-Jan-06

Z-VAD(OMe)-FMK
SYNONYMS	Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-039-M001		1 mg	170.00 USD
ALX-260-039-M005		5 mg	585.00 USD

Product Specification

SEQUENCE:	Z-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA:	C₂₂H₃₀N₃O₇F
MW:	467.5
CAS NUMBER:	187389-52-2
PURITY:	≥95.0%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING:	Keep cool and dry.

Product Description

Irreversible and cell permeable broad-spectrum caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP.1 cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine). For cell free assays use Prod. No. ALX-260-020.

Product Specific Literature References

Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes: S.C. Chow, et al.; FEBS Lett. 364, 134 (1995) Abstract
An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells: H. Zhu, et al.; FEBS Lett. 374, 303 (1995) Abstract
Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli: A. Sarin, et al.; J. Exp. Med. 184, 2445 (1996) Abstract
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32: E.A. Slee, et al.; Biochem. J. 315, 21 (1996) Abstract; Full Text
A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice: A. Farber, et al.; J. Vasc. Surg. 30, 752 (1999) Abstract; Full Text
Correlation of tumor necrosis factor α (TNF α) with high Caspase 3-like activity in myelodysplastic syndromes: S.D. Mundle, et al.; Cancer Lett. 140, 201 (1999) Abstract
TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk: P.F. Piguet, et al.; Lab. Invest. 79, 495 (1999) Abstract
Monocytic cell necrosis is mediated by potassium depletion and caspase-like protease: M. Warny & C.P. Kelly; Am. J. Physiol. 276, C717 (1999) Abstract; Full Text
Serine protease inhibitors suppress cytochrome c-mediated caspase-9 activation and apoptosis during hypoxia-reoxygenation: Z. Dong, et al.; Biochem. J. 347, 669 (2000) Abstract; Full Text
Apoptosis in Alzheimer's disease--an update: S. Shimohama; Apoptosis 5, 9 (2000) Abstract
Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo: C. Wiessner, et al.; Cell Mol. Biol. (Noisy-Le-Grand) 46, 53 (2000) Abstract

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