ALEXIS Biochemicals: Z-YVAD(OMe)-FMK

ALX-260-074

Revised 04-Nov-05

Z-YVAD(OMe)-FMK
SYNONYMS	Caspase-1 Inhibitor (Fluoromethylketone)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-074-M001		1 mg	331.00 USD

Product Specification

SEQUENCE:	Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA:	C₃₁H₃₉FN₄O₉
MW:	630.7
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING:	Packaged under inert gas.

Product Description

Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.

Product Specific Literature References

The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells: B.A. Eldadah, et al.; J. Neurosci. 17, 6105 (1997) Abstract; Full Text
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells: X.M. Zhang, et al.; Biochem. J. 340, 127 (1999) Abstract; Full Text
Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo: C. Wiessner, et al.; Cell Mol. Biol. (Noisy-Le-Grand) 46, 53 (2000) Abstract

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