ALEXIS Biochemicals: Zinc(II) Protoporphyrin IX

ALX-430-049

Revised 25-May-07

Zinc(II) Protoporphyrin IX
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Porphyrins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-049-M005		5 mg	20.00 USD
ALX-430-049-M025		25 mg	60.00 USD
ALX-430-049-M100		100 mg	180.00 USD

Product Specification

FORMULA:	C₃₄H₃₂N₄O₄Zn
MW:	626.0
CAS NUMBER:	15442-64-5
PURITY:	≥95% (TLC)
APPEARANCE:	Dark red solid.
SOLUBILITY:	Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING:	Protect from light and moisture.

Product Description

Potent and selective inhibitor of heme oxygenase, the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier.

Product Specific Literature References

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase: B. Brune & V. Ullrich; Mol. Pharmacol. 32, 497 (1987) Abstract
Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function: G.S. Marks, et al.; Can. J. Physiol.Pharmacol. 71, 753 (1993) Abstract
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus: M. Zhuo, et al; Science 260, 1946 (1993) Abstract
Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats: C. Kadoya, et al.; Stroke 26, 1035 (1995) Abstract; Full Text
Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase: L. Ny, et al.; Br. J. Pharmacol. 115, 186 (1995) Abstract
Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter: S. Chakder, et al.; J. Pharmacol. Exp. Ther. 277, 1376 (1996) Abstract
Inhibition of nitric oxide synthase isoforms by porphyrins: D.J. Wolff, et al.; Arch. Biochem. Biophys. 333, 27 (1996) Abstract
Pitfalls using metalloporphyrins in carbon monoxide research: L. Grundemar and L. Ny; TIPS 18, 193 (1997), (Review) Abstract
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock: S.F. Yet, et al.; J. Biol. Chem. 272, 4295 (1997) Abstract; Full Text
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity: L. Serfass and J.N. Burstyn; Arch. Biochem. Biophys. 359, 8 (1998) Abstract
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX: S. Rattan, et al.; Am. J. Physiol. 276, G138 (1999) Abstract; Full Text

Further Categories Containing This Product:

Heme Oxygenase/Related Products • Guanylyl Cyclases, Guanosine Phosphate Metabolism/Related Products • NOS Inhibitors (NOS Induction & Enzyme Activity)

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.