ALEXIS Biochemicals: trans-ACPD

ALX-550-020

Revised 11-Mar-08

trans-ACPD
SYNONYMS	(±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Glutamate Receptors (Metabotropic) / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-020-M005		5 mg	55.00 USD
ALX-550-020-M025		25 mg	220.00 USD

Product Specification

FORMULA:	C₇H₁₁NO₄
MW:	173.2
CAS NUMBER:	67684-64-4, 39026-64-7
RTECS:	GY4060000
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in dilute aqueous base or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.
IDENTITY:	Identity determined by NMR.
(1R,3S)-ACPD

Product Description

Equimolar mixture of (1S,3R)-ACPD (Prod. No. ALX-550-021) and (1R,3S)-ACPD. Selective agonist for mGluRs (active at both group I and group II mGluRs).

Product Specific Literature References

The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system: D.T. Monaghan, et al.; Annu. Rev. Pharmacol. Toxicol. 29, 365 (1989) Abstract
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor: E. Palmer, et al.; Eur. J. Pharmacol. 166, 585 (1989) Abstract
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects: D.D. Schoepp, et al.; J. Neurochem. 56, 1789 (1991) Abstract
Molecular diversity of glutamate receptors and implications for brain function: S. Nakanishi; Science 258, 597 (1992) Abstract
Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons: K.L. Klette, et al.; Brain Res. 756, 231 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes: Z.C. Ye & H. Sontheimer; Glia 25, 270 (1999) Abstract